主な研究業績

Onai T  Canonical Wnt/β-catenin and Notch signaling regulate animal/vegetal axial patterning in the cephalochordate amphioxus. Evolution and Development. https://doi.org/10.1111/ede.12273 (2018)

Onai T  The evolutionary origin of chordate segmentation: Revisiting the enterocoel theory. Theory in Biosciences. https://doi.org/10.1007/s12064-018-0260-y (2018)

Onai T, Adachi N, Kuratani S. Metamerism in cephalochordates and the problem of the vertebrate head. Int. Journal. Dev. Biol. 61:621-632. doi: 10.1387/ijdb.170121to (2017) 

Onai T, Aramaki T, Inomata H, Hirai T, Kuratani S.  Ancestral Mesodermal Reorganization and Evolution of the Vertebrate Head.  Zoological letters. 1:29 DOI: 10.1186/s40851-015-0030-3. (2015). 

Onai T, Aramaki T, Inomata H, Hirai T, Kuratani S. On the origin of vertebrate somites. Zoological letters. 1:33 DOI: 10.1186/s40851-015-0033-0.  (2015).

Onai T, Irie N, Kuratani S. The Evolutionary Origin of the Vertebrate Body Plan: The Problem of Head Segmentation. Annual review in genomics and human genetics. 15, 443-459. (2014).

Holland LZ and Onai T. Wiley Interdiscip Rev Dev Biol.Early development of cephalochordates (amphioxus). 1(2), 167-183. (2012).

Onai T, Takai A, Setiamarga DH, Holland LZ. Essential role of Dkk3 for head formation by inhibiting Wnt/b-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus. Evolution and Development. 14(4) 338-350. (2012).

Holland LZ and Onai T.  Analysis of gene function in amphioxus embryos by microinjection of mRNAs and morpholino-oligonucleotides. Methods in Molecular Biology. 770, 423-438. (2011)   

Onai T, J-Kai Y, Blitz IL, Cho KW, Holland LZ. Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus. Developmental Biology. 344, 377-389. (2010). 

Onai T, Lin, HC, Schubert M, Koop D, Osborne PW, Alvarez S, Alvarez R, Holland ND, Holland LZ. Retinoic acid and Wnt/b-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus. Developmental Biology. 332, 223-233. (2009). 

Onai T*, Matsuo-Takasaki M*, Inomata H, Aramaki T, Matsumura M, Yakura R, Sasai N, Sasai Y. XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. EMBO Journal, 26, 2350-2360. (2007)* These authors contributed equally. 

Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y. Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors. Mechanisms of Development, 123, 114-123. (2006).

Onai T, Sasai N, Matsui M, and Sasai Y. Xenopus XsalF: Anterior Neuroectoderm Specification by Attenuating Cellular Responsiveness to Wnt Signaling. Developmental Cell, 7, 95-106. (2004). 

©︎ Takayuki Onai